The interface of different materials correlates to the surface band bending, which leads to intriguing two-dimensional interfacial quantum effects. We are particularly interested in the electronics of the interface between semiconductors (such as layered transition metal chalcogenides) and Ion Liquids, forming an electric double layer (EDL) with a large local electric field up to 50 MV/cm. We focus on the electrical control of spin, orbit, charge degree of freedom and their interactions with Ion Liquid Gating technique.